Stereochemistry of Pyruvate Kinase, Pyruvate Carboxylase, and Malate Enzyme Reactions
نویسندگان
چکیده
منابع مشابه
Inhibitors of Pyruvate Carboxylase.
This review aims to discuss the varied types of inhibitors of biotin-dependent carboxylases, with an emphasis on the inhibitors of pyruvate carboxylase. Some of these inhibitors are physiologically relevant, in that they provide ways of regulating the cellular activities of the enzymes e.g. aspartate and prohibitin inhibition of pyruvate carboxylase. Most of the inhibitors that will be discusse...
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Background: The frequency of pyruvate kinase (PK) deficiency, an autosomal recessive defect, is approximately 3 per 10,000 individuals in Shiraz and surrounding areas, and is increased due to high consanguinity marriage frequency. The purpose of this study is to obtain data on the frequency and spectrum of gene mutation of PK in newborns, from Shiraz and surrounding areas. Materials and Methods...
متن کاملPyruvate Carboxylase from Chicken Liver
On the basis of initial velocity and product inhibition studies a nonclassical Ping Pong Bi Bi Uni Uni mechanism has been proposed for pyruvate carboxylase from chicken liver. The nonclassical feature of this mechanism is the proposal that each active site on the enzyme is composed of two separate and functionally distinct catalytic sites, i.e., a separate catalytic site exists for the reactant...
متن کاملProperties and function of yeast pyruvate carboxylase.
Cannata and Stoppani (1, 2) found that bakers’ yeast contains an adenosine diphosphate-dependent phosphoenolpyruvate carboxykinase, and they ascribed the essential physiological role of oxaloacetate synthesis to it. Doubts concerning their interpretation arose, however, when it was revealed (3, 4) that cellfree preparations of the same microorganism could catalyze the direct carboxylation of py...
متن کاملStructure, function and regulation of pyruvate carboxylase.
Pyruvate carboxylase (PC; EC 6.4.1.1), a member of the biotin-dependent enzyme family, catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetate. PC has been found in a wide variety of prokaryotes and eukaryotes. In mammals, PC plays a crucial role in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitter substances, and in glucose-induced insulin secretion by panc...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1970
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)62662-6